gpr-1 G-protein regulator 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gpr-1
Official Full Name: G-protein regulator 1
Primary source: WormBase:WBGene00001688
Locus tag: CELE_F22B7.13
See related: AllianceGenome:WB:WBGene00001688
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Is expressed in P lineage cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (8628932..8630776)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progeny of these animals (F2) inherit either only F0 maternal or only F0 paternal chromosomes, and thus descend from only either of their grandparents' gametes.
Title: Engineered non-Mendelian inheritance of entire parental genomes in C. elegans.
Four distinct in vivo phosphorylated LIN-5 residues were found to have critical functions in spindle positioning. Two of these residues form part of a 30 amino acid binding site for GPR-1, which we identified by reverse two-hybrid screening. These LIN-5 phosphorylations promote LIN-5-GPR-1/2 interaction and contribute to cortical pulling forces
Title: Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans.
GPR-1/2 can sense mechanical properties of the cortex, which may be important for GPR-1/2 function regulating spindle positioning and cytokinesis.
Title: G protein regulator 1 (GPR-1) localizes to cortical sites of artificial mechanical indentation in Caenorhabditis elegans zygotes.
Data demonstrate that GPB-1 depletion results in the loss of GPR-1/2 asymmetry during mitosis.
Title: Polarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos.
Dynamic localization of gpr-1 to cell cortex forces generation of domains during spindle positioning.
Title: Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning.
findings show that the GoLoco-containing proteins GPR-1 and GPR-2, as well as the Galpha subunits GOA-1 and GPA-16, were essential for generation of proper pulling forces in asymmetric spindle positioning
Title: Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Data suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division.
Title: RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F22B7.5 (e-PCR)
- UniSTS:309885

F22B7.6 (e-PCR)
- UniSTS:309886

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in aster	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein regulator 1

NP_498900.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8628932..8630776

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066499.5 → NP_498900.1 G-protein regulator 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498900.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95QJ7

Conserved Domains (1) summary

smart00390
Location:424 → 445

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases