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fli-1 Protein flightless-1 homolog [ Caenorhabditis elegans ]

Gene ID: 176215, updated on 2-Nov-2024

Summary

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Official Symbol
fli-1
Official Full Name
Protein flightless-1 homolog
Primary source
WormBase:WBGene00001443
Locus tag
CELE_B0523.5
See related
AllianceGenome:WB:WBGene00001443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Located in nucleus. Is expressed in body wall musculature; germ line; hermaphrodite gonad; and non-striated muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fli-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (8675297..8683736, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C-mannosyltransferase dpy-19 Neighboring gene Uncharacterized protein Neighboring gene P granule abnormality protein 2 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene Nicotinamide N-methyltransferase Neighboring gene putative 3-ketoacyl-CoA thiolase Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains. Goshima M, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092519
  2. FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans. Lu J, et al. BMC Dev Biol, 2008 May 16. PMID 18485202, Free PMC Article
  3. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Deng H, et al. Genetics, 2007 Oct. PMID 17720906, Free PMC Article
  4. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. Campbell HD, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248259, Free PMC Article
  5. Architecture of the cortical actomyosin network driving apical constriction in C. elegans. Zhang P, et al. J Cell Biol, 2023 Sep 4. PMID 37351566, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLI-1 controls germ line morphogenesis and rachis organization
    Title: FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans.
  2. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.
    Title: The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein flightless-1 homolog
NP_498913.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8675297..8683736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066512.6 → NP_498913.2  Protein flightless-1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498913.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34268, P90739, Q17331
    Conserved Domains (9) summary
    cd11280
    Location:629 → 717
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1034 → 1141
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:502 → 613
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:738 → 837
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd00116
    Location:129 → 373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:341 → 363
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:105 → 128
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:245 → 303
    LRR_8; Leucine rich repeat
    cl15697
    Location:1151 → 1250
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34268.2

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