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snap-29 Soluble NSF attachment protein 29 [ Caenorhabditis elegans ]

Gene ID: 176233, updated on 2-Nov-2024

Summary

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Official Symbol
snap-29
Official Full Name
Soluble NSF attachment protein 29
Primary source
WormBase:WBGene00019305
Locus tag
CELE_K02D10.5
See related
AllianceGenome:WB:WBGene00019305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in intracellular protein transmembrane transport; ovulation; and secretion. Located in apical plasma membrane and recycling endosome. Is expressed in several structures, including coelomocyte; excretory canal; gland cell; hermaphrodite somatic gonadal cell; and vulva. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See snap-29 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8776253..8777895)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Glycerol-3-phosphate phosphatase;Putative NipSnap protein K02D10.1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Zinc finger transcription factor family protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sugar modification inhibits autophagosome-lysosome fusion. Mizushima N. Nat Cell Biol, 2014 Dec. PMID 25434465
  2. Essential roles of snap-29 in C. elegans. Kang J, et al. Dev Biol, 2011 Jul 1. PMID 21545795, Free PMC Article
  3. A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane. Bidaud-Meynard A, et al. Development, 2019 Jun 5. PMID 31110027, Free PMC Article
  4. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Naegeli KM, et al. Dev Cell, 2017 Nov 20. PMID 29161591, Free PMC Article
  5. Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration. Akan I, et al. J Neurochem, 2018 Jan. PMID 29049853, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Soluble NSF attachment protein 29
NP_498940.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8776253..8777895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066539.9 → NP_498940.1  Soluble NSF attachment protein 29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498940.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83351
    Conserved Domains (2) summary
    cd15856
    Location:182 → 240
    SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
    cd15887
    Location:41 → 105
    SNARE_SNAP29N; N-terminal SNARE motif of SNAP29
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83351.1

Gene LinkOut

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