asna-1 ATPase asna-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asna-1
Official Full Name: ATPase asna-1
Primary source: WormBase:WBGene00014025
Locus tag: CELE_ZK637.5
See related: AllianceGenome:WB:WBGene00014025
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATP hydrolysis activity. Involved in detoxification of arsenic-containing substance and positive regulation of insulin secretion. Located in axon and neuronal cell body. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Used to study cancer. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asna-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (8895082..8896654)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
Title: A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans.
Title: Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans.
Data show that the parental gene, asna-1, was not targeted by miR-249, presumably because asna-1 is involved in insulin secretion; the cleavage of the asna-1 mRNA might be so detrimental and could be under selective pressure to escape miR-249 targeting.
Title: Degradome sequencing reveals an endogenous microRNA target in C. elegans.
findings show that worms lacking activity of the asna-1 gene arrest growth reversibly at the L1 stage even when food is abundant; proposed that ASNA1 is an evolutionarily conserved modulator of insulin signaling
Title: ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.
As(III)- & Sb(III)-stimulated ArsA ATPase activities are not restricted to bacteria. asna-1 gene from C. elegans encodes functional ArsA ATPase whose activity is stimulated by As(III) & Sb(III), which is critical for As(III) & Sb(III) tolerance.
Title: Caenorhabditis elegans expresses a functional ArsA.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK637.5 (e-PCR)
- UniSTS:308291

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in detoxification of arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATPase asna-1

NP_498965.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8895082..8896654

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066564.4 → NP_498965.1 ATPase asna-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498965.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30632

Conserved Domains (2) summary

COG0003
Location:29 → 333

ArsA; Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism]

pfam02374
Location:18 → 336

ArsA_ATPase; Anion-transporting ATPase