pde-2 putative 3',5'-cyclic phosphodiesterase pde-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pde-2
Official Full Name: putative 3',5'-cyclic phosphodiesterase pde-2
Primary source: WormBase:WBGene00011146
Locus tag: CELE_R08D7.6
See related: AllianceGenome:WB:WBGene00011146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and protein homodimerization activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and regulation of cGMP-mediated signaling. Predicted to be active in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and synaptic membrane. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pde-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (8975069..8981897, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

R08D7.6 (e-PCR)
- UniSTS:321628

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGMP-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to alkaline pH	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hydrogen peroxide	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative 3',5'-cyclic phosphodiesterase pde-2

NP_001022705.2

Confirmed by transcript evidence

NP_001022706.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8975069..8981897 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027535.7 → NP_001022706.2 putative 3',5'-cyclic phosphodiesterase pde-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022706.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P30645

Conserved Domains (2) summary

smart00065
Location:174 → 319

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:418 → 654

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001027534.7 → NP_001022705.2 putative 3',5'-cyclic phosphodiesterase pde-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022705.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P30645, Q65ZC7, Q7JMU8

Conserved Domains (2) summary

smart00065
Location:177 → 322

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:421 → 657

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase