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zif-1 Zinc finger-interacting factor 1 [ Caenorhabditis elegans ]

Gene ID: 176274, updated on 2-Nov-2024

Summary

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Official Symbol
zif-1
Official Full Name
Zinc finger-interacting factor 1
Primary source
WormBase:WBGene00006977
Locus tag
CELE_F59B2.6
See related
AllianceGenome:WB:WBGene00006977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryo development and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zif-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (9002779..9004839)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit rpn-6.2 Neighboring gene Secreted protein Neighboring gene Ras-related protein rab-6.1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line. Schwartz AZA, et al. Genetics, 2023 Nov 1. PMID 37647858, Free PMC Article
  2. emb-4 is a conserved gene required for efficient germline-specific chromatin remodeling during Caenorhabditis elegans embryogenesis. Checchi PM, et al. Genetics, 2006 Dec. PMID 17028322, Free PMC Article
  3. Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. Armenti ST, et al. Development, 2014 Dec. PMID 25377555, Free PMC Article
  4. Multiple RNA-binding proteins function combinatorially to control the soma-restricted expression pattern of the E3 ligase subunit ZIF-1. Oldenbroek M, et al. Dev Biol, 2012 Mar 15. PMID 22265679, Free PMC Article
  5. zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression. Guven-Ozkan T, et al. Development, 2010 Oct. PMID 20826530, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.
    Title: ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.
  2. It was shown that ZIF-1 expression in embryos is regulated by five maternally-supplied RNA-binding proteins. POS-1, MEX-3, and SPN-4 function as repressors of ZIF-1 expression, whereas MEX-5 and MEX-6 antagonize this repression.
    Title: Multiple RNA-binding proteins function combinatorially to control the soma-restricted expression pattern of the E3 ligase subunit ZIF-1.
  3. zif-1 encodes the substrate-binding subunit of the E3 ligase for PIE-1 degradation during germline specification.
    Title: zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression.
  4. results show that five CCCH finger proteins, components of the Caenorhabditis elegans germ plasm, are targeted for degradation by the novel CCCH-finger-binding protein ZIF-1 [ZIF-1]
    Title: Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Zinc finger-interacting factor 1
NP_498992.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9002779..9004839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066591.6 → NP_498992.2  Zinc finger-interacting factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498992.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34482
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34482.2

Gene LinkOut

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