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rab-6.1 Ras-related protein rab-6.1 [ Caenorhabditis elegans ]

Gene ID: 176275, updated on 2-Nov-2024

Summary

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Official Symbol
rab-6.1
Official Full Name
Ras-related protein rab-6.1
Primary source
WormBase:WBGene00004269
Locus tag
CELE_F59B2.7
See related
AllianceGenome:WB:WBGene00004269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Involved in cortical granule exocytosis and cuticle development. Located in Golgi cisterna and cortical granule. Is expressed in several structures, including RIG; command interneuron; gonad; intestine; and vulva. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-6.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (9004821..9005955, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit rpn-6.2 Neighboring gene Secreted protein Neighboring gene Zinc finger-interacting factor 1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative modeling of Rab6 proteins: identification of key residues and their interactions with guanine nucleotides. Mulukala Narasimha SK, et al. J Mol Model, 2013 Apr. PMID 23334348
  2. Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans. Kimura K, et al. J Cell Sci, 2012 Dec 1. PMID 22992455
  3. RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans. Zhang D, et al. PLoS One, 2016. PMID 26891225, Free PMC Article
  4. The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans. Michaud P, et al. PLoS Genet, 2021 Apr. PMID 33826611, Free PMC Article
  5. The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology. Luo L, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613545, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAB-6.1 is an important molecule for the timely exocytosis of the cortical granules during oocyte-to-embryo transition.
    Title: Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cortical granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cortical granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras-related protein rab-6.1
NP_498993.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9004821..9005955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066592.7 → NP_498993.1  Ras-related protein rab-6.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34213
    UniProtKB/TrEMBL
    I7EVJ8
    Conserved Domains (2) summary
    smart00175
    Location:12 → 170
    RAB; Rab subfamily of small GTPases
    cd01861
    Location:12 → 172
    Rab6; Rab GTPase family 6 (Rab6)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34213.1

Gene LinkOut

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