U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ikke-1 Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [ Caenorhabditis elegans ]

Gene ID: 176278, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ikke-1
Official Full Name
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1
Primary source
WormBase:WBGene00011299
Locus tag
CELE_R107.4
See related
AllianceGenome:WB:WBGene00011299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in protein phosphorylation and regulation of autophagy. Located in cytoplasm. Is expressed in anal sphincter muscle; intestinal muscle; and oocyte. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ikke-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (9046039..9050700, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Sodium-dependent high-affinity dicarboxylate transporter 2 Neighboring gene ATP-dependent (S)-NAD(P)H-hydrate dehydratase Neighboring gene Uncharacterized protein Neighboring gene Protein CLASP-2;TOG domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
  2. The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. Plowman GD, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570119, Free PMC Article
  3. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
  4. Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Kell A, et al. Free Radic Biol Med, 2007 Dec 1. PMID 17964427, Free PMC Article
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It has been proposed that ALLO-1 is the allophagy receptor whose function is regulated by IKKE-1-dependent phosphorylation.
    Title: The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1
NP_001359523.1
  • Confirmed by transcript evidence
NP_001379435.1
  • Confirmed by transcript evidence
NP_871627.1
  • Confirmed by transcript evidence
NP_871628.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9046039..9050700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181899.7 → NP_871628.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871628.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32742
    Conserved Domains (2) summary
    COG0515
    Location:25 → 404
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:27 → 275
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001372639.1 → NP_001359523.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21453
    Location:27 → 275
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001392170.1 → NP_001379435.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21453
    Location:27 → 275
    PKc_like; Protein Kinases, catalytic domain

  4. NM_181898.4 → NP_871627.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32741, P32742, Q5FC85
    Conserved Domains (2) summary
    COG0515
    Location:25 → 404
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:27 → 275
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32742.5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools