U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cya-1 G2/mitotic-specific cyclin-A1 [ Caenorhabditis elegans ]

Gene ID: 176287, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cya-1
Official Full Name
G2/mitotic-specific cyclin-A1
Primary source
WormBase:WBGene00000863
Locus tag
CELE_ZK507.6
See related
AllianceGenome:WB:WBGene00000863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in meiotic cell cycle. Predicted to be part of cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1) and CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cya-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (9106699..9109272, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene Delta and osm-11 homolog protein 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Coordination of cell proliferation and cell fate determination by CES-1 snail. Yan B, et al. PLoS Genet, 2013 Oct. PMID 24204299, Free PMC Article
  2. Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression. Kreutzer MA, et al. J Cell Sci, 1995 Jun. PMID 7545687
  3. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. van der Voet M, et al. Cell Cycle, 2009 Dec 15. PMID 19829076, Free PMC Article
  4. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Cowan CR, et al. Nat Cell Biol, 2006 Dec. PMID 17115027
  5. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Shirayama M, et al. Curr Biol, 2006 Jan 10. PMID 16343905

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G2/mitotic-specific cyclin-A1
NP_499018.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9106699..9109272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066617.10 → NP_499018.1  G2/mitotic-specific cyclin-A1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499018.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34638
    Conserved Domains (2) summary
    pfam00134
    Location:215 → 338
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:343 → 459
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34638.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.