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pir-2 TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4 [ Caenorhabditis elegans ]

Gene ID: 176323, updated on 2-Nov-2024

Summary

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Official Symbol
pir-2
Official Full Name
TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4
Primary source
WormBase:WBGene00010037
Locus tag
CELE_F54C8.4
See related
AllianceGenome:WB:WBGene00010037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable polynucleotide 5'-phosphatase activity. Predicted to be involved in protein dephosphorylation. Is expressed in AB and pharynx. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pir-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (9441557..9443634, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone H3-like centromeric protein cpar-1 Neighboring gene Abnormal embryogenesis protein 30 Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase F54C8.1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. Takagi T, et al. Cell, 1997 Jun 13. PMID 9200605
  2. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables polynucleotide 5'-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4
NP_001254988.1
  • Confirmed by transcript evidence
NP_001254989.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9441557..9443634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268059.2 → NP_001254988.1  putative tyrosine-protein phosphatase F54C8.4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34442
    Conserved Domains (1) summary
    cl21483
    Location:66 → 166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001268060.3 → NP_001254989.1  TYR_PHOSPHATASE_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6R1
    Conserved Domains (1) summary
    cl28904
    Location:1 → 96
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34442.1

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