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F54C8.7 AH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176326, updated on 2-Nov-2024

Summary

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Official Symbol
F54C8.7
Official Full Name
AH domain-containing protein
Primary source
WormBase:WBGene00010040
Locus tag
CELE_F54C8.7
See related
AllianceGenome:WB:WBGene00010040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phospholipid binding activity. Involved in IRE1-mediated unfolded protein response. Located in mitochondrion. Is expressed in pharynx. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1) and ARFIP2 (ADP ribosylation factor interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F54C8.7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (9451591..9454062, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTP-binding protein Rheb homolog 1 Neighboring gene Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AH domain-containing protein
NP_001022604.1
  • Confirmed by transcript evidence
NP_001254995.1
  • Confirmed by transcript evidence
NP_001370276.1
  • Confirmed by transcript evidence
NP_001379523.1
  • Confirmed by transcript evidence
NP_001379524.1
  • Confirmed by transcript evidence
NP_871661.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9451591..9454062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027433.7 → NP_001022604.1  AH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34445
    Conserved Domains (1) summary
    cd07660
    Location:74 → 274
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  2. NM_001382962.2 → NP_001370276.1  AH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6R3
    Conserved Domains (1) summary
    cd07660
    Location:56 → 256
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  3. NM_001392175.1 → NP_001379524.1  AH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6R5
    Conserved Domains (1) summary
    cl12013
    Location:1 → 140
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_181932.7 → NP_871661.1  AH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34445, Q86D24
    Conserved Domains (1) summary
    cd07660
    Location:93 → 293
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  5. NM_001392174.1 → NP_001379523.1  AH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6R4
    Conserved Domains (1) summary
    cd07660
    Location:9 → 209
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  6. NM_001268066.3 → NP_001254995.1  AH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1MN62
    Conserved Domains (1) summary
    cd07660
    Location:43 → 243
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34445.3

Gene LinkOut

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