rheb-1 GTP-binding protein Rheb homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rheb-1
Official Full Name: GTP-binding protein Rheb homolog 1
Primary source: WormBase:WBGene00010038
Locus tag: CELE_F54C8.5
See related: AllianceGenome:WB:WBGene00010038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in positive regulation of TOR signaling and small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head neurons; hypodermis; intestine; tail neurons; and vulval muscle. Orthologous to several human genes including RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rheb-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (9454163..9456030, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
Title: The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
essential role of signalling by RHEB-1 in intermittent fasting (IF)-induced longevity and gene expression changes, suggesting a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway
Title: Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54C8.5 (e-PCR)
- UniSTS:318257

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP-binding protein Rheb homolog 1

NP_499079.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9454163..9456030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066678.4 → NP_499079.1 GTP-binding protein Rheb homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499079.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34443

Conserved Domains (2) summary

smart00010
Location:13 → 177

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04137
Location:13 → 207

RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase