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bre-3 Beta-1,4-mannosyltransferase bre-3 [ Caenorhabditis elegans ]

Gene ID: 176332, updated on 2-Nov-2024

Summary

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Official Symbol
bre-3
Official Full Name
Beta-1,4-mannosyltransferase bre-3
Primary source
WormBase:WBGene00000268
Locus tag
CELE_B0464.4
See related
AllianceGenome:WB:WBGene00000268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable beta-1,4-mannosyltransferase activity. Involved in carbohydrate biosynthetic process and response to toxic substance. Located in cytoplasm. Is expressed in neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bre-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (9469900..9485451, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Barrier-to-autointegration factor 1 Neighboring gene Neuropeptide-like peptide 36 Neighboring gene Aspartate--tRNA ligase, cytoplasmic Neighboring gene RNA polymerase-associated protein CTR9 Neighboring gene Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity. Wohlschlager T, et al. J Biol Chem, 2011 Sep 2. PMID 21757752, Free PMC Article
  2. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Barrows BD, et al. J Biol Chem, 2007 Feb 2. PMID 17135259
  3. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Marroquin LD, et al. Genetics, 2000 Aug. PMID 10924467, Free PMC Article
  4. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. Griffitts JS, et al. J Biol Chem, 2003 Nov 14. PMID 12944392
  5. Use of RNAi as a preliminary tool for screening putative receptors of nematicidal toxins from Bacillus thuringiensis. García-Montelongo M, et al. Arch Microbiol, 2021 May. PMID 33432376

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-1,4-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-1,4-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-1,4-mannosyltransferase bre-3
NP_499087.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9469900..9485451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066686.8 → NP_499087.2  Beta-1,4-mannosyltransferase bre-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499087.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03562
    Conserved Domains (2) summary
    COG1215
    Location:154 → 453
    BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
    pfam13632
    Location:184 → 382
    Glyco_trans_2_3; Glycosyl transferase family group 2

RNA

  1. NR_132454.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03562.2

Gene LinkOut

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