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trpp-3 Trafficking protein particle complex subunit 3 homolog [ Caenorhabditis elegans ]

Gene ID: 176344, updated on 2-Nov-2024

Summary

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Official Symbol
trpp-3
Official Full Name
Trafficking protein particle complex subunit 3 homolog
Primary source
WormBase:WBGene00014222
Locus tag
CELE_ZK1098.5
See related
AllianceGenome:WB:WBGene00014222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and protein secretion. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network membrane and cytosol. Orthologous to several human genes including TRAPPC3 (trafficking protein particle complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trpp-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (9525552..9527083)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Clustered mitochondria protein homolog Neighboring gene Pre-mRNA-processing factor 40 homolog B;WW domain-containing protein ZK1098.1 Neighboring gene Small ribosomal subunit protein mS23 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP. Kim YG, et al. Nat Struct Mol Biol, 2005 Jan. PMID 15608655
  2. Caenorhabditis elegans exoskeleton collagen COL-19: an adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology. Thein MC, et al. Dev Dyn, 2003 Mar. PMID 12619137
  3. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
  4. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article
  5. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Simmer F, et al. Curr Biol, 2002 Aug 6. PMID 12176360

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cis-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Trafficking protein particle complex subunit 3 homolog
NP_499100.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9525552..9527083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066699.7 → NP_499100.1  Trafficking protein particle complex subunit 3 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499100.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34605
    Conserved Domains (1) summary
    cd14942
    Location:16 → 167
    TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34605.1

Gene LinkOut

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