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ced-7 ABC transporter ced-7;ABC transporter domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176352, updated on 2-Nov-2024

Summary

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Official Symbol
ced-7
Official Full Name
ABC transporter ced-7;ABC transporter domain-containing protein
Primary source
WormBase:WBGene00000421
Locus tag
CELE_C48B4.4
See related
AllianceGenome:WB:WBGene00000421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Is expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ced-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (9570390..9580089, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene putative acyl-coenzyme A oxidase acox-1.5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transbilayer phospholipid movement and the clearance of apoptotic cells. Williamson P, et al. Biochim Biophys Acta, 2002 Dec 30. PMID 12531537
  2. Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. Grau GE, et al. J Soc Biol, 2005. PMID 16471259
  3. C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Zhang Y, et al. Curr Biol, 2012 Jul 24. PMID 22727700
  4. let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury. Basu A, et al. Proc Natl Acad Sci U S A, 2017 Nov 21. PMID 29109254, Free PMC Article
  5. Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms. Li Z, et al. PLoS Genet, 2015 Jun. PMID 26061275, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. let-7 miRNA inhibits functional restoration via EFF-1-mediated axonal self-fusion by reducing ced-7 expression.
    Title: let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury.
  2. The results reveal the existence of a WLDS/Nmnat-independent axonal degeneration pathway in C. elegans, conservation of the axonal clearance machinery, and a function for CED-7 and NRF-5 in this process.
    Title: The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.
  3. CED-7 and TTR-52 may promote the efflux of phosphatidylserine (PS) from apoptotic cells through the generation of extracellular PS vesicles, which lead to exoplasmic leaflet (exPS) expression on phagocytes via TTR-52 and CED-1 to facilitate cell corpse clearance.
    Title: CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
  4. Review. CED-7 is akey player in engulfment. Its mode of action is unusual in the panorama of engulfment receptors since they act as lipid transporters. Loss of CED-7 has phenotypic consequences exclusively on engulfment.
    Title: Immunopathological consequences of the loss of engulfment genes: the case of ABCA1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATPase-coupled transmembrane transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid efflux IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of distal tip cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ABC transporter ced-7;ABC transporter domain-containing protein
NP_001021225.1
  • Partially confirmed by transcript evidence
NP_001255012.1
  • Partially confirmed by transcript evidence
NP_001366984.1
  • Partially confirmed by transcript evidence
NP_499115.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9570390..9580089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026054.4 → NP_001021225.1  ABC transporter ced-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021225.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34358
    Conserved Domains (4) summary
    cd03263
    Location:1366 → 1578
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:533 → 818
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:947 → 1312
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:1087 → 1281
    ABC2_membrane_4; ABC-2 family transporter protein

  2. NM_066714.5 → NP_499115.2  ABC transporter ced-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499115.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34358
    Conserved Domains (4) summary
    cd03263
    Location:1364 → 1576
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:533 → 818
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:947 → 1310
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:1085 → 1279
    ABC2_membrane_4; ABC-2 family transporter protein

  3. NM_001268083.3 → NP_001255012.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255012.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0P274
    Conserved Domains (4) summary
    cd03263
    Location:1433 → 1645
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:600 → 885
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:1014 → 1379
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:1154 → 1348
    ABC2_membrane_4; ABC-2 family transporter protein

  4. NM_001379863.2 → NP_001366984.1  ABC transporter ced-7 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76287, P34358, P34359
    Conserved Domains (1) summary
    TIGR01257
    Location:152 → 1693
    rim_protein; retinal-specific rim ABC transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34358.6

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