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rpac-19 putative DNA-directed RNA polymerases I and III subunit RPAC2 [ Caenorhabditis elegans ]

Gene ID: 176362, updated on 2-Nov-2024

Summary

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Official Symbol
rpac-19
Official Full Name
putative DNA-directed RNA polymerases I and III subunit RPAC2
Primary source
WormBase:WBGene00010230
Locus tag
CELE_F58A4.9
See related
AllianceGenome:WB:WBGene00010230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpac-19 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (9629246..9629885, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Helix-loop-helix protein 11 Neighboring gene ncRNA Neighboring gene Tubulin gamma chain Neighboring gene putative ubiquitin-conjugating enzyme E2 7 Neighboring gene Gex-3-interacting protein 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes in human obesity loci are causal obesity genes in C. elegans. Ke W, et al. PLoS Genet, 2021 Sep. PMID 34492009, Free PMC Article
  2. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Akay A, et al. Dev Cell, 2017 Aug 7. PMID 28787591, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative DNA-directed RNA polymerases I and III subunit RPAC2
NP_499132.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9629246..9629885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066731.7 → NP_499132.1  putative DNA-directed RNA polymerases I and III subunit RPAC2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499132.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34476
    Conserved Domains (1) summary
    cd07029
    Location:52 → 135
    RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34476.1

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