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ubc-7 putative ubiquitin-conjugating enzyme E2 7 [ Caenorhabditis elegans ]

Gene ID: 176363, updated on 2-Nov-2024

Summary

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Official Symbol
ubc-7
Official Full Name
putative ubiquitin-conjugating enzyme E2 7
Primary source
WormBase:WBGene00006704
Locus tag
CELE_F58A4.10
See related
AllianceGenome:WB:WBGene00006704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ubc-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (9630097..9631167, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tubulin gamma chain Neighboring gene putative DNA-directed RNA polymerases I and III subunit RPAC2 Neighboring gene Gex-3-interacting protein 13 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Individual point mutations in two ERAD E2 ubiquitin-conjugating enzymes do not affect Caenorhabditis elegans spontaneous reversal frequency. Oswald M, et al. MicroPubl Biol, 2020 Nov 19. PMID 33274319, Free PMC Article
  2. O-GlcNAcylation confers protection against Staphylococcus aureus infection in Caenorhabditis elegans through ubiquitination. Vigneshwari L, et al. RSC Adv, 2018 Jun 21. PMID 35540126, Free PMC Article
  3. Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein. Vartiainen S, et al. Neurobiol Dis, 2006 Jun. PMID 16626960
  4. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Springer W, et al. Hum Mol Genet, 2005 Nov 15. PMID 16204351
  5. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ubiquitin-conjugating enzyme E2 7
NP_499133.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9630097..9631167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066732.7 → NP_499133.1  putative ubiquitin-conjugating enzyme E2 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499133.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34477
    Conserved Domains (1) summary
    COG5078
    Location:8 → 161
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34477.1

Gene LinkOut

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