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mog-1 putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 [ Caenorhabditis elegans ]

Gene ID: 176409, updated on 2-Nov-2024

Summary

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Official Symbol
mog-1
Official Full Name
putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
Primary source
WormBase:WBGene00003389
Locus tag
CELE_K03H1.2
See related
AllianceGenome:WB:WBGene00003389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Involved in feminization of hermaphroditic germ-line. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Is expressed widely. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mog-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (9952060..9956215, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene L-fucokinase domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Apoptosis-linked gene 2-interacting protein X 1 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. Puoti A, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737793, Free PMC Article
  2. Sequenced Breakpoints of Crossover Suppressor/Inversion qC1. Edgley ML, et al. MicroPubl Biol, 2021. PMID 34746683, Free PMC Article
  3. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. van Haaften G, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15326288, Free PMC Article
  4. The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1. Kasturi P, et al. Dev Biol, 2010 Aug 15. PMID 20478293
  5. The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family. Puoti A, et al. Mol Cell Biol, 1999 Mar. PMID 10022905, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in feminization of hermaphroditic germ-line IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
NP_499212.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9952060..9956215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066811.10 → NP_499212.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34498
    Conserved Domains (6) summary
    smart00487
    Location:437 → 620
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:840 → 922
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:458 → 596
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:622 → 778
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:956 → 1056
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    pfam08648
    Location:114 → 239
    DUF1777; Protein of unknown function (DUF1777)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34498.2

Gene LinkOut

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