spop-1 Speckle-type POZ protein homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spop-1
Official Full Name: Speckle-type POZ protein homolog
Primary source: WormBase:WBGene00011815
Locus tag: CELE_T16H12.5
See related: AllianceGenome:WB:WBGene00011815
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to several human genes including SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spop-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (10090862..10098081, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T16H12.5 (e-PCR)
- UniSTS:308051

T16H12.6 (e-PCR)
- UniSTS:310871

STS3-185 (e-PCR)
- UniSTS:242029

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Speckle-type POZ protein homolog

NP_001022764.1

Confirmed by transcript evidence

NP_001022765.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10090862..10098081 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027593.2 → NP_001022764.1 Speckle-type POZ protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34568, Q5CZ49

Conserved Domains (4) summary

smart00225
Location:266 → 368

BTB; Broad-Complex, Tramtrack and Bric a brac

cd03774
Location:92 → 230

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd14734
Location:368 → 430

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:255 → 365

BTB; BTB/POZ domain
NM_001027594.6 → NP_001022765.1 Speckle-type POZ protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022765.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34568

Conserved Domains (4) summary

smart00225
Location:224 → 326

BTB; Broad-Complex, Tramtrack and Bric a brac

cd03774
Location:50 → 188

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd14734
Location:326 → 388

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:213 → 323

BTB; BTB/POZ domain