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div-1 DNA polymerase alpha subunit B [ Caenorhabditis elegans ]

Gene ID: 176439, updated on 2-Nov-2024

Summary

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Official Symbol
div-1
Official Full Name
DNA polymerase alpha subunit B
Primary source
WormBase:WBGene00001002
Locus tag
CELE_R01H10.1
See related
AllianceGenome:WB:WBGene00001002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Is expressed in gonad; pharynx; vulva; and vulval precursor cell. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See div-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (10245056..10248559, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene EGF-like domain-containing protein Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene Coronin-like protein cor-1 Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee SJ, et al. Development, 2004 Jun. PMID 15115755
  2. Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Powell-Coffman JA, et al. Dev Biol, 1996 Sep 15. PMID 8812143
  3. Reproductive isolation in Caenorhabditis: terminal phenotypes of hybrid embryos. Baird SE, et al. Evol Dev, 2000 Jan-Feb. PMID 11256419
  4. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. Yoon DS, et al. FEBS J, 2018 Jul. PMID 29775245, Free PMC Article
  5. emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6. Nishiwaki K, et al. Mol Gen Genet, 1993 Jun. PMID 8391108

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase alpha subunit B
NP_499268.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10245056..10248559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066867.6 → NP_499268.1  DNA polymerase alpha subunit B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21625
    Conserved Domains (1) summary
    pfam04042
    Location:324 → 531
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21625.3

Gene LinkOut

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