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enu-3.1 ENhancer of Uncoordination [ Caenorhabditis elegans ]

Gene ID: 176463, updated on 2-Nov-2024

Summary

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Official Symbol
enu-3.1
Official Full Name
ENhancer of Uncoordination
Primary source
WormBase:WBGene00010362
Locus tag
CELE_H04D03.1
See related
AllianceGenome:WB:WBGene00010362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in axon extension involved in axon guidance. Located in neuronal cell body. Is expressed in head; nervous system; and seam cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See enu-3.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (10436276..10438142)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog Neighboring gene ncRNA Neighboring gene MLX-interacting protein;Ovule protein Neighboring gene DUF1330 domain-containing protein;PHD-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans. Florica RO, et al. Dev Biol, 2017 Oct 1. PMID 28694018
  2. ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans. Yee CS, et al. Dev Biol, 2011 Apr 15. PMID 21295567
  3. ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans. Yee C, et al. Dev Dyn, 2014 Mar. PMID 24123761
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway.
    Title: The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.
  2. identified a novel mutant, enu-3 (enhancer of Unc), that enhances the motor neuron axon outgrowth defects observed in strains that lack either the UNC-5 receptor or its ligand UNC-6/Netrin
    Title: ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.
  3. ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
    Title: ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in axon extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ENhancer of Uncoordination
NP_499302.1
  • Product from WormBase gene class enu;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10436276..10438142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066901.6 → NP_499302.1  ENhancer of Uncoordination [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499302.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45607
    Conserved Domains (1) summary
    pfam04795
    Location:149 → 202
    PAPA-1; PAPA-1-like conserved region
Nucleotide Protein
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