U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

atx-2 Ataxin-2 homolog;Sm domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176465, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
atx-2
Official Full Name
Ataxin-2 homolog;Sm domain-containing protein
Primary source
WormBase:WBGene00000231
Locus tag
CELE_D2045.1
See related
AllianceGenome:WB:WBGene00000231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of cell cycle process; and regulation of gene expression. Located in cytoplasm. Is expressed in body wall musculature; dorsal nerve cord; germ line; gonad; and ventral nerve cord. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2) and ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See atx-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (10461389..10468051)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Protein NLRC3 Neighboring gene ECm29 Proteasome adaptor and Scaffold Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Cullin-1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes. Beath EA, et al. Elife, 2024 Jul 30. PMID 39078879, Free PMC Article
  2. The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans. Kiehl TR, et al. J Mol Neurosci, 2000 Dec. PMID 11303786
  3. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Gnazzo MM, et al. Mol Biol Cell, 2016 Oct 15. PMID 27559134, Free PMC Article
  4. The Period protein homolog LIN-42 regulates germline development in C. elegans. Berardi S, et al. Mech Dev, 2018 Oct. PMID 30144508
  5. Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Dec. PMID 28027322, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
    Title: Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
  2. atx-2 regulates the mechanistic target of rapamycin (mTOR) pathway, downstream of AMP-activated protein kinase (AMPK) and upstream of ribosomal protein S6 kinase and mTOR complex 1 (TORC1), by its direct association with Rab GDP dissociation inhibitor beta.
    Title: Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.
  3. ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins.
    Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of temperature stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in detection of temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of centrosome location IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of centrosome location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oocyte fate determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of female gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fertilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiosis I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cytokinetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of centrosome duplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of germ cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitotic cytokinetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of spindle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ataxin-2 homolog;Sm domain-containing protein
NP_001366696.1
  • Partially confirmed by transcript evidence
NP_001367113.1
  • Partially confirmed by transcript evidence
NP_001367186.1
  • Confirmed by transcript evidence
NP_001367241.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10461389..10468051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379897.1 → NP_001367241.1  Sm domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6K7, G5ED29, Q5FC83
    UniProtKB/TrEMBL
    D4PH96
    Conserved Domains (3) summary
    pfam09606
    Location:626 → 807
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam06741
    Location:283 → 338
    LsmAD; LsmAD domain
    pfam14438
    Location:126 → 198
    SM-ATX; Ataxin 2 SM domain

  2. NM_001379898.1 → NP_001366696.1  Ataxin-2 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6K7, G5ED29, Q5FC83
    Conserved Domains (3) summary
    pfam09606
    Location:518 → 699
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam06741
    Location:175 → 230
    LsmAD; LsmAD domain
    pfam14438
    Location:18 → 90
    SM-ATX; Ataxin 2 SM domain

  3. NM_001379899.1 → NP_001367186.1  Ataxin-2 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6K7, G5ED29, Q5FC83
    Conserved Domains (3) summary
    pfam09606
    Location:518 → 699
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam06741
    Location:175 → 230
    LsmAD; LsmAD domain
    pfam14438
    Location:18 → 90
    SM-ATX; Ataxin 2 SM domain

  4. NM_001379900.3 → NP_001367113.1  Ataxin-2 homolog [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools