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hpd-1 4-hydroxyphenylpyruvate dioxygenase [ Caenorhabditis elegans ]

Gene ID: 176473, updated on 2-Nov-2024

Summary

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Official Symbol
hpd-1
Official Full Name
4-hydroxyphenylpyruvate dioxygenase
Primary source
WormBase:WBGene00001993
Locus tag
CELE_T21C12.2
See related
AllianceGenome:WB:WBGene00001993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hpd-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (10535526..10537680)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-like protein 68 Neighboring gene XK-related protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia. Fisher AL, et al. J Biol Chem, 2008 Apr 4. PMID 18227072, Free PMC Article
  2. DAF-16 target genes that control C. elegans life-span and metabolism. Lee SS, et al. Science, 2003 Apr 25. PMID 12690206
  3. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
  4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-hydroxyphenylpyruvate dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
4-hydroxyphenylpyruvate dioxygenase
NP_001369878.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10535526..10537680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382982.2 → NP_001369878.1  4-hydroxyphenylpyruvate dioxygenase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22633
    Conserved Domains (1) summary
    TIGR01263
    Location:17 → 382
    4HPPD; 4-hydroxyphenylpyruvate dioxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22633.1

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