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emg-1 Ribosomal RNA small subunit methyltransferase nep-1 [ Caenorhabditis elegans ]

Gene ID: 176488, updated on 2-Nov-2024

Summary

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Official Symbol
emg-1
Official Full Name
Ribosomal RNA small subunit methyltransferase nep-1
Primary source
WormBase:WBGene00012652
Locus tag
CELE_Y39A1A.14
See related
AllianceGenome:WB:WBGene00012652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable rRNA (pseudouridine) methyltransferase activity and rRNA binding activity. Predicted to be involved in rRNA base methylation. Predicted to be located in nucleolus. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See emg-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (10649519..10650908)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Origin recognition complex subunit 1 Neighboring gene ORC (Origin Recognition Complex) subunit Neighboring gene Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 Neighboring gene ncRNA Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  2. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (pseudouridine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (pseudouridine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (pseudouridine) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA base methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ribosomal RNA small subunit methyltransferase nep-1
NP_001379033.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10649519..10650908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392200.1 → NP_001379033.1  Ribosomal RNA small subunit methyltransferase nep-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XX15
    Conserved Domains (1) summary
    cd18088
    Location:28 → 225
    Nep1-like; 18S rRNA (pseudouridine(1248)-N1)-methyltransferase Nep1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XX15.1

Gene LinkOut

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