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tbb-1 Tubulin beta chain [ Caenorhabditis elegans ]

Gene ID: 176501, updated on 2-Nov-2024

Summary

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Official Symbol
tbb-1
Official Full Name
Tubulin beta chain
Primary source
WormBase:WBGene00006536
Locus tag
CELE_K01G5.7
See related
AllianceGenome:WB:WBGene00006536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in spindle microtubule. Is expressed in several structures, including excretory gland cell; intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6; congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa) and TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbb-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (10740868..10742432, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Arf-GAP domain-containing protein Neighboring gene Protein FAM32A Neighboring gene Exostosin-2 homolog Neighboring gene GTP-binding nuclear protein ran-1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. Ellis GC, et al. J Cell Sci, 2004 Jan 26. PMID 14702387
  2. Motor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant. Baran R, et al. PLoS One, 2010 Mar 11. PMID 20300184, Free PMC Article
  3. Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo. Wright AJ, et al. Mol Biol Cell, 2003 Nov. PMID 12937270, Free PMC Article
  4. The Caenorhabditis elegans microtubule-severing complex MEI-1/MEI-2 katanin interacts differently with two superficially redundant beta-tubulin isotypes. Lu C, et al. Mol Biol Cell, 2004 Jan. PMID 14565976, Free PMC Article
  5. Roles for two partially redundant alpha-tubulins during mitosis in early Caenorhabditis elegans embryos. Phillips JB, et al. Cell Motil Cytoskeleton, 2004 Jun. PMID 15083533

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tubulin beta chain
NP_499367.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10740868..10742432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066966.9 → NP_499367.1  Tubulin beta chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17921
    Conserved Domains (2) summary
    PLN00220
    Location:1 → 447
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:2 → 426
    beta_tubulin; The beta-tubulin family
Nucleotide Protein
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