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sca-1 Calcium-transporting ATPase [ Caenorhabditis elegans ]

Gene ID: 176512, updated on 2-Nov-2024

Summary

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Official Symbol
sca-1
Official Full Name
Calcium-transporting ATPase
Primary source
WormBase:WBGene00004736
Locus tag
CELE_K11D9.2
See related
AllianceGenome:WB:WBGene00004736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and multicellular organismal-level water homeostasis. Located in several cellular components, including nuclear envelope; nuclear outer membrane-endoplasmic reticulum membrane network; and sarcoplasmic reticulum. Is expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to several human genes including ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sca-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (10811906..10816844, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two isoforms of sarco/endoplasmic reticulum calcium ATPase (SERCA) are essential in Caenorhabditis elegans. Cho JH, et al. Gene, 2000 Dec 31. PMID 11167007
  2. The sarco-endoplasmic reticulum Ca2+ ATPase is required for development and muscle function in Caenorhabditis elegans. Zwaal RR, et al. J Biol Chem, 2001 Nov 23. PMID 11559701
  3. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. Delgado SE, et al. eNeuro, 2023 Jul. PMID 37385728, Free PMC Article
  4. mir-233 modulates the unfolded protein response in C. elegans during Pseudomonas aeruginosa infection. Dai LL, et al. PLoS Pathog, 2015 Jan. PMID 25569229, Free PMC Article
  5. The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16. Martin AA, et al. Cell Calcium, 2018 Jun. PMID 29748129

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in cytosolic baseline calcium levels in sca-1 and other mutants indicates a calcium-driven regulation mechanism of the alpha7-like NAChR ACR-16.
    Title: The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in IRE1-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calcium ion import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calcium-transporting ATPase
NP_001122708.1
  • Partially confirmed by transcript evidence
NP_499385.3
  • Confirmed by transcript evidence
NP_499386.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10811906..10816844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066984.9 → NP_499385.3  Calcium-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499385.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XU13
    Conserved Domains (6) summary
    TIGR01116
    Location:52 → 990
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:95 → 342
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:785 → 988
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 71
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:607 → 713
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:423 → 529
    Cation_ATPase; Cation transport ATPase (P-type)

  2. NM_066985.7 → NP_499386.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEK8
    Conserved Domains (6) summary
    TIGR01116
    Location:52 → 990
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:95 → 342
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:785 → 988
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 71
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:607 → 713
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:423 → 529
    Cation_ATPase; Cation transport ATPase (P-type)

  3. NM_001129236.4 → NP_001122708.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WI68
    Conserved Domains (5) summary
    TIGR01116
    Location:1 → 863
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:2 → 215
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:658 → 861
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam12710
    Location:480 → 586
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:296 → 402
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein
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