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athp-1 PHD-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176517, updated on 2-Nov-2024

Summary

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Official Symbol
athp-1
Official Full Name
PHD-type domain-containing protein
Primary source
WormBase:WBGene00008081
Locus tag
CELE_C44B9.4
See related
AllianceGenome:WB:WBGene00008081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Sin3-type complex. Predicted to be active in nucleus. Orthologous to human PHF12 (PHD finger protein 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See athp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (10882360..10893672)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Vps54_N domain-containing protein Neighboring gene Lgl_C domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene DNA endonuclease activator Ctp1 C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interplay Between Polymorphic Short Tandem Repeats and Gene Expression Variation in Caenorhabditis elegans. Zhang G, et al. Mol Biol Evol, 2023 Apr 4. PMID 36999565, Free PMC Article
  2. SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics. Baytek G, et al. Biotechniques, 2022 Jun. PMID 35698829
  3. Caenorhabditis elegans algn-2 Is Critical for Longevity Conferred by Enhanced Nonsense-Mediated mRNA Decay. Kim EJE, et al. iScience, 2020 Nov 20. PMID 33225240, Free PMC Article
  4. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article
  5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PHD-type domain-containing protein
NP_499397.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10882360..10893672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066996.7 → NP_499397.2  PHD-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499397.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18605
    Conserved Domains (3) summary
    smart00240
    Location:1019 → 1076
    FHA; Forkhead associated domain
    cd15534
    Location:220 → 266
    PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
    cd15567
    Location:62 → 103
    PHD4_NSD; PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins
Nucleotide Protein
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