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com-1 DNA endonuclease activator Ctp1 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176518, updated on 2-Nov-2024

Summary

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Official Symbol
com-1
Official Full Name
DNA endonuclease activator Ctp1 C-terminal domain-containing protein
Primary source
WormBase:WBGene00008082
Locus tag
CELE_C44B9.5
See related
AllianceGenome:WB:WBGene00008082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See com-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (10896363..10901836)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PHD-type domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Cuticlin-6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization. Harrell K, et al. Mutat Res, 2021 Jan-Jun. PMID 33975127, Free PMC Article
  2. COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining. Lemmens BB, et al. PLoS Genet, 2013. PMID 23408909, Free PMC Article
  3. NHJ-1 Is Required for Canonical Nonhomologous End Joining in Caenorhabditis elegans. Vujin A, et al. Genetics, 2020 Jul. PMID 32457132, Free PMC Article
  4. Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Girard C, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686104, Free PMC Article
  5. A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination. Penkner A, et al. EMBO J, 2007 Dec 12. PMID 18007596, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our results uncover the potentially lethal properties of NHEJ during meiosis and identify a critical role for COM-1 in NHEJ inhibition and CO assurance in germ cells
    Title: COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA double-strand break processing involved in repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA endonuclease activator Ctp1 C-terminal domain-containing protein
NP_499398.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10896363..10901836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066997.4 → NP_499398.3  DNA endonuclease activator Ctp1 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499398.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18606
Nucleotide Protein
Heading Accession and Version

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