unc-119 GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-119
Official Full Name: GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119
Primary source: WormBase:WBGene00006843
Locus tag: CELE_M142.1
See related: AllianceGenome:WB:WBGene00006843
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lipid binding activity. Involved in several processes, including negative regulation of axon extension; regulation of egg-laying behavior; and regulation of nematode pharyngeal pumping. Located in axon. Is expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-119 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (10902641..10908935)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate that ARL-3 is a unique small GTPase with unusual high intrinsic GDP release but low intrinsic GTP binding rate. Importantly, ARL-13 acts as a nucleotide exchange factor (GEF) of ARL-3, while UNC-119 can stabilize the GTP binding of ARL-3. We further show that excess inactivated ARL-3 compromises ciliogenesis.
Title: GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
we show that removal of either of two critical P-granule components, PGL-1 or GLH-1, is sufficient to cause germ cells to express UNC-119::GFP and MYO-3 and to display RNA accumulation defects similar to those observed after depletion of P granules. Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate.
Title: Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline.
the RIBEYE-Munc119 interaction is essential for synaptic transmission at the photoreceptor ribbon synapse.
Title: RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses.
Unc-119 mutants result in age-related effects on M2 neurons.
Title: A genetic analysis of axon guidance in the C elegans pharynx.
UNC-119 function is necessary for the correct development of the Caenorhabditis elegans nervous system
Title: Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M142.1 (e-PCR)
- UniSTS:319537

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119

NP_001255088.1

Confirmed by transcript evidence

NP_001255089.1

Confirmed by transcript evidence

NP_001255090.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10902641..10908935

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268159.3 → NP_001255088.1 GMP phosphodiesterase delta subunit domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255088.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EGP9

Conserved Domains (1) summary

pfam05351
Location:89 → 242

GMP_PDE_delta; GMP-PDE, delta subunit
NM_001268160.4 → NP_001255089.1 Protein unc-119 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255089.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10658

Conserved Domains (1) summary

pfam05351
Location:64 → 217

GMP_PDE_delta; GMP-PDE, delta subunit
NM_001268161.3 → NP_001255090.1 GMP phosphodiesterase delta subunit domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255090.1

Status: REVIEWED

UniProtKB/TrEMBL

C0P283

Conserved Domains (1) summary

pfam05351
Location:45 → 197

GMP_PDE_delta; GMP-PDE, delta subunit