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cut-6 Cuticlin-6 [ Caenorhabditis elegans ]

Gene ID: 176520, updated on 2-Nov-2024

Summary

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Official Symbol
cut-6
Official Full Name
Cuticlin-6
Primary source
WormBase:WBGene00000853
Locus tag
CELE_M142.2
See related
AllianceGenome:WB:WBGene00000853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Located in alae of collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermal cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cut-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (10911460..10916665)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA endonuclease activator Ctp1 C-terminal domain-containing protein Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Homeobox protein vab-7 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans. Sapio MR, et al. Dev Biol, 2005 Jun 1. PMID 15936343
  2. M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Muriel JM, et al. Dev Biol, 2003 Aug 15. PMID 12921736
  3. Identification and characterization of epicuticular proteins of nematodes sharing motifs with cuticular proteins of arthropods. Betschart B, et al. PLoS One, 2022. PMID 36301857, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterization of the gene M142.2; findings show that this is a developmentally regulated gene important for cuticle structure
    Title: M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in alae of collagen and cuticulin-based cuticle extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cuticlin-6
NP_499400.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10911460..10916665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066999.8 → NP_499400.2  Cuticlin-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499400.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21540
    Conserved Domains (2) summary
    smart00241
    Location:233 → 480
    ZP; Zona pellucida (ZP) domain
    pfam00092
    Location:48 → 208
    VWA; von Willebrand factor type A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21540.2

Gene LinkOut

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