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vab-7 Homeobox protein vab-7 [ Caenorhabditis elegans ]

Gene ID: 176521, updated on 2-Nov-2024

Summary

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Official Symbol
vab-7
Official Full Name
Homeobox protein vab-7
Primary source
WormBase:WBGene00006873
Locus tag
CELE_M142.4
See related
AllianceGenome:WB:WBGene00006873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including Caap; Capp; neurons; somatic nervous system; and tail hypodermis. Orthologous to human EVX1 (even-skipped homeobox 1) and EVX2 (even-skipped homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vab-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10920344..10926041)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Cuticlin-6 Neighboring gene pseudo Neighboring gene AD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus. Jungblut B, et al. Development, 2001 Jan. PMID 11124120
  2. The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory. Esmaeili B, et al. Development, 2002 Feb. PMID 11861469
  3. Proprioceptive coupling within motor neurons drives C. elegans forward locomotion. Wen Q, et al. Neuron, 2012 Nov 21. PMID 23177960, Free PMC Article
  4. Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7. Ahringer J. Genes Dev, 1996 May 1. PMID 8654927
  5. An Organ-Specific Differentiation Gene, pha-1, from Caenorhabditis elegans. Schnabel H, et al. Science, 1990 Nov 2. PMID 17810870

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox protein vab-7
NP_499401.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10920344..10926041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067000.6 → NP_499401.1  Homeobox protein vab-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499401.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23093, Q93899
    Conserved Domains (1) summary
    pfam00046
    Location:72 → 124
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93899.2

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