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mrt-2 Cell cycle checkpoint protein RAD1 homolog mrt-2 [ Caenorhabditis elegans ]

Gene ID: 176608, updated on 2-Nov-2024

Summary

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Official Symbol
mrt-2
Official Full Name
Cell cycle checkpoint protein RAD1 homolog mrt-2
Primary source
WormBase:WBGene00003417
Locus tag
CELE_Y41C4A.14
See related
AllianceGenome:WB:WBGene00003417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable damaged DNA binding activity. Involved in DNA metabolic process and intracellular signal transduction. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mrt-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (11746766..11750175)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein SUP-1 Neighboring gene ncRNA Neighboring gene Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Neighboring gene Peptidase S26 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Cheung I, et al. Nucleic Acids Res, 2004. PMID 15247331, Free PMC Article
  2. Telomeres: a tale of ends. Lundblad V. Nature, 2000 Jan 13. PMID 10646584
  3. High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans. Cheung I, et al. Nucleic Acids Res, 2006. PMID 16407328, Free PMC Article
  4. The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Cheng Z, et al. Toxicol Lett, 2014 Mar 21. PMID 24445071
  5. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Ahmed S, et al. Nature, 2000 Jan 13. PMID 10646593

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cell cycle checkpoint protein RAD1 homolog mrt-2
NP_499521.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11746766..11750175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067120.5 → NP_499521.1  Cell cycle checkpoint protein RAD1 homolog mrt-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499521.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EC44
    Conserved Domains (1) summary
    pfam02144
    Location:11 → 246
    Rad1; Repair protein Rad1/Rec1/Rad17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EC44.1

Gene LinkOut

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