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rsp-8 RNA-binding protein;RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176613, updated on 2-Nov-2024

Summary

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Official Symbol
rsp-8
Official Full Name
RNA-binding protein;RRM domain-containing protein
Primary source
WormBase:WBGene00004705
Locus tag
CELE_C18D11.4
See related
AllianceGenome:WB:WBGene00004705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in several structures, including enteric muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human TRA2A (transformer 2 alpha homolog) and TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rsp-8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (11826418..11830974)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ACB domain-containing protein Neighboring gene Fcf2 domain-containing protein Neighboring gene pre-microRNA mir-1832.1 Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein Neighboring gene L-dopachrome isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
  2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein;RRM domain-containing protein
NP_001255142.1
  • Confirmed by transcript evidence
NP_001255143.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11826418..11830974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268213.4 → NP_001255142.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTZ2
    Conserved Domains (1) summary
    cd12363
    Location:77 → 154
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. NM_001268214.3 → NP_001255143.1  RNA-binding protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU77
Nucleotide Protein
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