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tsen-2 tRNA-intron lyase [ Caenorhabditis elegans ]

Gene ID: 176619, updated on 2-Nov-2024

Summary

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Official Symbol
tsen-2
Official Full Name
tRNA-intron lyase
Primary source
WormBase:WBGene00013231
Locus tag
CELE_Y56A3A.11
See related
AllianceGenome:WB:WBGene00013231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleus. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tsen-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (11894793..11898269, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Amidase domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene Monoglyceride lipase faah-4 Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA ligation in neurons by RtcB inhibits axon regeneration. Kosmaczewski SG, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100902, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-intron endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-intron endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-intron endonuclease complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA-intron lyase
NP_499543.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11894793..11898269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067142.9 → NP_499543.2  tRNA-intron lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499543.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U218
    Conserved Domains (1) summary
    pfam01974
    Location:163 → 235
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
Nucleotide Protein
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