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faah-4 Monoglyceride lipase faah-4 [ Caenorhabditis elegans ]

Gene ID: 176620, updated on 2-Nov-2024

Summary

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Official Symbol
faah-4
Official Full Name
Monoglyceride lipase faah-4
Primary source
WormBase:WBGene00013232
Locus tag
CELE_Y56A3A.12
See related
AllianceGenome:WB:WBGene00013232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable amidase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See faah-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (11899337..11906909, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene tRNA-intron lyase Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Chen AL, et al. Nat Chem Biol, 2019 May. PMID 30911178, Free PMC Article
  2. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. Hernandez-Cravero B, et al. PLoS Genet, 2022 Nov. PMID 36346800, Free PMC Article
  3. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Arnold A, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378320, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid amide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid amide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Monoglyceride lipase faah-4
NP_001379259.1
  • Confirmed by transcript evidence
NP_499545.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11899337..11906909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392214.1 → NP_001379259.1  Monoglyceride lipase faah-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl18951
    Location:80 → 565
    Amidase

  2. NM_067144.7 → NP_499545.1  Monoglyceride lipase faah-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499545.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I4C5, Q9U216, Q9U217
    Conserved Domains (1) summary
    cl18951
    Location:112 → 597
    Amidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U217.1

Gene LinkOut

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