pph-4.1 Serine/threonine-protein phosphatase 4 catalytic subunit 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pph-4.1
Official Full Name: Serine/threonine-protein phosphatase 4 catalytic subunit 1
Primary source: WormBase:WBGene00004085
Locus tag: CELE_Y75B8A.30
See related: AllianceGenome:WB:WBGene00004085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine phosphatase activity. Involved in chiasma assembly; embryo development; and regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. Located in centrosome and cytoplasm. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_499603.1

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The following sections contain reference sequences that belong to a specific genome build. Explain