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his-72 Histone H3.3 type 2 [ Caenorhabditis elegans ]

Gene ID: 176660, updated on 2-Nov-2024

Summary

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Official Symbol
his-72
Official Full Name
Histone H3.3 type 2
Primary source
WormBase:WBGene00001946
Locus tag
CELE_Y49E10.6
See related
AllianceGenome:WB:WBGene00001946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Is expressed in several structures, including male. Orthologous to several human genes including H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See his-72 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (12367475..12369050, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF221-domain-containing protein Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 8 Neighboring gene Glutaredoxin domain-containing protein Neighboring gene Serine/threonine-protein phosphatase 4 catalytic subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans. Ooi SL, et al. Nucleic Acids Res, 2010 Mar. PMID 19966274, Free PMC Article
  2. Endogenous expression and localization of HIS-72::mTurquoise2 in C. elegans. Sloan DE, et al. MicroPubl Biol, 2021. PMID 34604717, Free PMC Article
  3. A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions In Vivo. Han S, et al. Genes (Basel), 2023 Feb 14. PMID 36833412, Free PMC Article
  4. Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development. Bratic I, et al. Nucleic Acids Res, 2009 Apr. PMID 19181702, Free PMC Article
  5. Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. Ooi SL, et al. PLoS Genet, 2006 Jun. PMID 16846252, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone H3.3 type 2
NP_001255162.1
  • Confirmed by transcript evidence
NP_001255163.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12367475..12369050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268234.5 → NP_001255163.1  Histone H3.3 type 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255163.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08898, Q9TW44, Q9U281
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional

  2. NM_001268233.3 → NP_001255162.1  Histone H3.3 type 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2K8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U281.3

Gene LinkOut

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