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pph-4.2 Serine/threonine-protein phosphatase 4 catalytic subunit 2 [ Caenorhabditis elegans ]

Gene ID: 176663, updated on 18-Sep-2024

Summary

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Official Symbol
pph-4.2
Official Full Name
Serine/threonine-protein phosphatase 4 catalytic subunit 2
Primary source
WormBase:WBGene00004086
Locus tag
CELE_Y49E10.3
See related
AllianceGenome:WB:WBGene00004086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity; protein serine phosphatase activity; and protein threonine phosphatase activity. Predicted to be involved in protein dephosphorylation. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See pph-4.2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (12374173..12377248, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone H3.3 type 2 Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 8 Neighboring gene Glutaredoxin domain-containing protein Neighboring gene pseudo Neighboring gene Thioredoxin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. Sumiyoshi E, et al. J Cell Sci, 2002 Apr 1. PMID 11896188
  2. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Han X, et al. Genetics, 2009 Mar. PMID 19087961, Free PMC Article
  3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein phosphatase 4 catalytic subunit 2
NP_001022898.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12374173..12377248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027727.6 → NP_001022898.1  Serine/threonine-protein phosphatase 4 catalytic subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022898.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q966Q3, Q9XTT8
    Conserved Domains (2) summary
    PTZ00239
    Location:16 → 321
    PTZ00239; serine/threonine protein phosphatase 2A; Provisional
    cd07415
    Location:16 → 303
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTT8.1

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