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Y49E10.4 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176664, updated on 2-Nov-2024

Summary

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Official Symbol
Y49E10.4
Official Full Name
Thioredoxin domain-containing protein
Primary source
WormBase:WBGene00013030
Locus tag
CELE_Y49E10.4
See related
AllianceGenome:WB:WBGene00013030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to be active in endoplasmic reticulum. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y49E10.4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (12379000..12380588, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase 4 catalytic subunit 2 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Thioredoxin domain-containing protein
NP_499613.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12379000..12380588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067212.8 → NP_499613.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTU8
    Conserved Domains (2) summary
    cd02983
    Location:269 → 405
    P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
    cd03001
    Location:26 → 127
    PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
Nucleotide Protein
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