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ttm-1 Zinc transporter ttm-1 [ Caenorhabditis elegans ]

Gene ID: 176715, updated on 2-Nov-2024

Summary

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Official Symbol
ttm-1
Official Full Name
Zinc transporter ttm-1
Primary source
WormBase:WBGene00012712
Locus tag
CELE_Y39E4A.2
See related
AllianceGenome:WB:WBGene00012712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion transmembrane transporter activity. Involved in response to cadmium ion and response to nematicide. Predicted to be located in apical plasma membrane and cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Is expressed in head neurons; hypodermis; intestine; and vulva. Orthologous to human SLC30A3 (solute carrier family 30 member 3) and SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ttm-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (12952969..12966995, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Glutamate decarboxylase;Glutamate decarboxylase 1 Neighboring gene Uncharacterized protein Neighboring gene 2-oxoisovalerate dehydrogenase subunit alpha;2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Neighboring gene DUF155 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zinc oxide/graphene oxide nanocomposites specifically remediated Cd-contaminated soil via reduction of bioavailability and ecotoxicity of Cd. Li Y, et al. Sci Total Environ, 2024 Aug 25. PMID 38825205
  2. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Roh HC, et al. PLoS Genet, 2013 May. PMID 23717214, Free PMC Article
  3. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article
  4. A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Roh HC, et al. Nucleic Acids Res, 2015 Jan. PMID 25552416, Free PMC Article
  5. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Huffman DL, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15256590, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We showed that TTM-1 isoforms function in tandem with CDF-2, which is also induced by high levels of cytoplasmic zinc and reduces cytoplasmic zinc levels by sequestering zinc in lysosome-related organelles
    Title: ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nematicide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc transporter ttm-1
NP_001299904.1
  • Confirmed by transcript evidence
NP_499691.1
  • Confirmed by transcript evidence
NP_499692.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12952969..12966995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067291.8 → NP_499692.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499692.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AU82, O45922, O45923
    Conserved Domains (1) summary
    TIGR01297
    Location:114 → 393
    CDF; cation diffusion facilitator family transporter

  2. NM_067290.6 → NP_499691.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45922
    Conserved Domains (1) summary
    TIGR01297
    Location:95 → 374
    CDF; cation diffusion facilitator family transporter

  3. NM_001312975.3 → NP_001299904.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU82
    Conserved Domains (1) summary
    TIGR01297
    Location:37 → 316
    CDF; cation diffusion facilitator family transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45923.1

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