dnj-17 J domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dnj-17
Official Full Name: J domain-containing protein
Primary source: WormBase:WBGene00001035
Locus tag: CELE_T03F6.2
See related: AllianceGenome:WB:WBGene00001035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in cytoplasm. Is expressed in head neurons and intestine. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-17 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (13390850..13393339, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered function of the DNJ-17 modulates locomotor circuit activity in a Caenorhabditis elegans seizure model.
Title: Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T03F6.1 (e-PCR)
- UniSTS:320607

T03F6.2 (e-PCR)
- UniSTS:310638

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: J domain-containing protein

NP_499759.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13390850..13393339 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067358.6 → NP_499759.2 J domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O62360

Conserved Domains (4) summary

COG5269
Location:4 → 275

ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]

sd00020
Location:293 → 315

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00226
Location:3 → 66

DnaJ; DnaJ domain

pfam12171
Location:292 → 315

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding