U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cua-1 P-type Cu(+) transporter [ Caenorhabditis elegans ]

Gene ID: 176770, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cua-1
Official Full Name
P-type Cu(+) transporter
Primary source
WormBase:WBGene00000834
Locus tag
CELE_Y76A2A.2
See related
AllianceGenome:WB:WBGene00000834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables copper ion transmembrane transporter activity. Involved in copper ion transport. Located in vacuolar membrane. Is expressed in hypodermis; intestine; neurons; and pharynx. Used to study Menkes disease. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7A (ATPase copper transporting alpha). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cua-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (13439730..13455307, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene rRNA methyltransferase 2, mitochondrial Neighboring gene MIP18 family protein F45G2.10 Neighboring gene ABC transporter domain-containing protein Neighboring gene Major sperm protein Neighboring gene Cytochrome b-c1 complex subunit 6

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A new Caenorhabditis elegans model to study copper toxicity in Wilson disease. Catalano F, et al. Traffic, 2024 Jan. PMID 37886910,
  2. Caenorhabditis elegans cDNA for a Menkes/Wilson disease gene homologue and its function in a yeast CCC2 gene deletion mutant. Sambongi Y, et al. J Biochem, 1997 Jun. PMID 9354393
  3. Essential Cys-Pro-Cys motif of Caenorhabditis elegans copper transport ATPase. Yoshimizu T, et al. Biosci Biotechnol Biochem, 1998 Jun. PMID 9692213
  4. CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior in Caenorhabditis elegans. Yuan S, et al. J Biol Chem, 2018 Jul 13. PMID 29784876, Free PMC Article
  5. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, et al. J Biol Chem, 2017 Jan 6. PMID 27881675, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type divalent copper transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type monovalent copper transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion export IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in copper ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular copper ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
P-type Cu(+) transporter
NP_001255202.1
  • Confirmed by transcript evidence
NP_001255203.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13439730..13455307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268273.4 → NP_001255202.1  P-type Cu(+) transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE14, O17537
    Conserved Domains (5) summary
    COG2217
    Location:330 → 1117
    ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
    COG4087
    Location:961 → 1082
    COG4087; Soluble P-type ATPase [General function prediction only]
    cd00371
    Location:253 → 317
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    pfam00122
    Location:534 → 775
    E1-E2_ATPase; E1-E2 ATPase
    pfam00403
    Location:332 → 389
    HMA; Heavy-metal-associated domain

  2. NM_001268274.3 → NP_001255203.1  P-type Cu(+) transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED40, O17537
    Conserved Domains (5) summary
    COG2217
    Location:208 → 995
    ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
    COG4087
    Location:839 → 960
    COG4087; Soluble P-type ATPase [General function prediction only]
    cd00371
    Location:131 → 195
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    pfam00122
    Location:412 → 653
    E1-E2_ATPase; E1-E2 ATPase
    pfam00403
    Location:210 → 267
    HMA; Heavy-metal-associated domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous