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acc-4 Acetylcholine-gated ion channel acc-4;Ligand-Gated ion Channel [ Caenorhabditis elegans ]

Gene ID: 176778, updated on 2-Nov-2024

Summary

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Official Symbol
acc-4
Official Full Name
Acetylcholine-gated ion channel acc-4;Ligand-Gated ion Channel
Primary source
WormBase:WBGene00012099
Locus tag
CELE_T27E9.9
See related
AllianceGenome:WB:WBGene00012099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in axon; postsynapse; and presynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acc-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (13480665..13484124, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene L-Fucosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system. Von Stetina SE, et al. Genome Biol, 2007. PMID 17612406, Free PMC Article
  2. Cholinergic receptor-Wnt pathway controls immune activation by sensing intestinal dysfunction. Ren J, et al. Cell Rep, 2022 Nov 1. PMID 36323254, Free PMC Article
  3. Locomotion modulates olfactory learning through proprioception in C. elegans. Zhan X, et al. Nat Commun, 2023 Jul 27. PMID 37500635, Free PMC Article
  4. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acetylcholine-gated ion channel acc-4;Ligand-Gated ion Channel
NP_001379219.1
  • Confirmed by transcript evidence
NP_001407497.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13480665..13484124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392232.2 → NP_001379219.1  Acetylcholine-gated ion channel acc-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U358
    Conserved Domains (2) summary
    cd18990
    Location:74 → 259
    LGIC_ECD_GABAAR; gamma-aminobutyric acid receptor extracellular domain
    cd19049
    Location:263 → 396
    LGIC_TM_anion; transmembrane domain of anionic Cys-loop neurotransmitter-gated ion channels, includes GABAAR, GlyR and GluCl

  2. NM_001420560.1 → NP_001407497.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I621
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U358.1

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