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act-5 Actin [ Caenorhabditis elegans ]

Gene ID: 176793, updated on 2-Nov-2024

Summary

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Official Symbol
act-5
Official Full Name
Actin
Primary source
WormBase:WBGene00000067
Locus tag
CELE_T25C8.2
See related
AllianceGenome:WB:WBGene00000067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity. Involved in several processes, including larval feeding behavior; microvillus assembly; and positive regulation of eating behavior. Located in microvillar actin bundle and terminal web. Is expressed in excretory cell; gonad; intestine; pharyngeal-intestinal valve; and rectal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See act-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (13604412..13606066, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene pseudo Neighboring gene Carbohydrate kinase FGGY N-terminal domain-containing protein Neighboring gene STI1 domain-containing protein Neighboring gene Protein PFC0760c-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Szumowski SC, et al. Cell Microbiol, 2016 Jan. PMID 26147591, Free PMC Article
  2. Orsay δ Protein Is Required for Nonlytic Viral Egress. Yuan W, et al. J Virol, 2018 Jul 15. PMID 29743360, Free PMC Article
  3. ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation. MacQueen AJ, et al. Mol Biol Cell, 2005 Jul. PMID 15872090, Free PMC Article
  4. Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction. Egge N, et al. Dev Cell, 2019 Dec 2. PMID 31794717, Free PMC Article
  5. Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. Estes KA, et al. PLoS Pathog, 2011 Sep. PMID 21949650, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-onset ACT-5 phosphorylation within its troponin binding site destabilizes actin networks.
    Title: Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
  2. Act-5 has a microvillus-specific function
    Title: ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microvillar actin bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal web IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Actin
NP_499809.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13604412..13606066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067408.7 → NP_499809.1  Actin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499809.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45815
    Conserved Domains (2) summary
    smart00268
    Location:6 → 375
    ACTIN; Actin
    cl17037
    Location:1 → 375
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
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