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lit-1 Serine/threonine kinase NLK [ Caenorhabditis elegans ]

Gene ID: 176808, updated on 2-Nov-2024

Summary

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Official Symbol
lit-1
Official Full Name
Serine/threonine kinase NLK
Primary source
WormBase:WBGene00003048
Locus tag
CELE_W06F12.1
See related
AllianceGenome:WB:WBGene00003048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell fate specification; and polarity specification of proximal/distal axis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Is expressed in several structures, including E; amphid sheath cell; hermaphrodite gonad; pharynx; and tail hypodermis. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lit-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (13701993..13724404)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein dyf-2 Neighboring gene Systemic RNA interference defective protein 2 Neighboring gene Cullin-2 Neighboring gene Peptidyl-prolyl cis-trans isomerase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc finger protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental biology. The worm keeps turning. Bowerman B. Nature, 1997 Nov 20. PMID 9384368
  2. Identification of C. elegans DAF-12-binding sites, response elements, and target genes. Shostak Y, et al. Genes Dev, 2004 Oct 15. PMID 15489294, Free PMC Article
  3. Meta-Boolean models of asymmetric division patterns in the C. elegans intestinal lineage: Implications for the posterior boundary of intestinal twist. Pettersson S, et al. Worm, 2013 Jan 1. PMID 24058861, Free PMC Article
  4. Binary specification of the embryonic lineage in Caenorhabditis elegans. Kaletta T, et al. Nature, 1997 Nov 20. PMID 9384382
  5. In vivo identification of regulators of cell invasion across basement membranes. Matus DQ, et al. Sci Signal, 2010 May 4. PMID 20442418, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data support a model in which WRM-1, which can undergo homotypic interaction, binds LIT-1 and thereby generates a kinase complex in which LIT-1 molecules are situated in a conformation enabling autophosphorylation.
    Title: β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.
  2. Results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size.
    Title: Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans.
  3. SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1
    Title: Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.
  4. Overexpressing lit-1 causes heterochronic defects opposite to those in lit-1(lf) mutants. LIT-1 exhibits a periodic expression pattern in seam cells within each larval stage
    Title: Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in anatomical structure morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polarity specification of proximal/distal axis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of serine/threonine protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine/threonine kinase NLK
NP_001022805.1
  • Confirmed by transcript evidence
NP_001022806.1
  • Confirmed by transcript evidence
NP_001022807.1
  • Confirmed by transcript evidence
NP_001022808.1
  • Confirmed by transcript evidence
NP_001367102.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13701993..13724404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027637.6 → NP_001022808.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022808.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U9Y8
    Conserved Domains (2) summary
    cd07853
    Location:206 → 583
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    smart00220
    Location:211 → 498
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  2. NM_001027634.3 → NP_001022805.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022805.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62395, Q69YW9, Q8WQB7, Q9U343, Q9U9Y8, Q9UA07, Q9Y198
    Conserved Domains (2) summary
    cd07853
    Location:239 → 616
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    smart00220
    Location:244 → 531
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  3. NM_001027635.6 → NP_001022806.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022806.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U9Y8
    Conserved Domains (2) summary
    cd07853
    Location:67 → 444
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    smart00220
    Location:72 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  4. NM_001379989.1 → NP_001367102.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07853
    Location:59 → 436
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

  5. NM_001027636.4 → NP_001022807.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022807.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U9Y8
    Conserved Domains (2) summary
    cd07853
    Location:42 → 419
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    smart00220
    Location:47 → 334
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U9Y8.1

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