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toca-2 Transducer of Cdc42-dependent actin assembly protein 2 homolog [ Caenorhabditis elegans ]

Gene ID: 176812, updated on 2-Nov-2024

Summary

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Official Symbol
toca-2
Official Full Name
Transducer of Cdc42-dependent actin assembly protein 2 homolog
Primary source
WormBase:WBGene00010663
Locus tag
CELE_K08E3.3
See related
AllianceGenome:WB:WBGene00010663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including negative regulation of protein localization to adherens junction; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in several cellular components, including cell-cell junction; intracellular vesicle; and plasma membrane. Is expressed in spermatheca and uterus. Orthologous to human FNBP1 (formin binding protein 1); FNBP1L (formin binding protein 1 like); and TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See toca-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (13755896..13759445)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Holbert S, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12604778, Free PMC Article
  2. A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling. Bai Z, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775511, Free PMC Article
  3. Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans. Ouellette MH, et al. J Mol Cell Biol, 2016 Aug. PMID 26578656, Free PMC Article
  4. Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. Giuliani C, et al. PLoS Genet, 2009 Oct. PMID 19798448, Free PMC Article
  5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOCA-1 and TOCA-2 are important for the regulation of Clathrin-mediated endocytic processes during oocyte growth, and in the control of epithelial morphogenesis in developing embryos.
    Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic ectodermal digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic ectodermal digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to adherens junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transducer of Cdc42-dependent actin assembly protein 2 homolog
NP_499838.2
  • Confirmed by transcript evidence
NP_499839.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13755896..13759445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067438.5 → NP_499839.2  Transducer of Cdc42-dependent actin assembly protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499839.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XUS7
    Conserved Domains (3) summary
    cd07653
    Location:8 → 267
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11619
    Location:356 → 431
    HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11911
    Location:551 → 606
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

  2. NM_067437.6 → NP_499838.2  Transducer of Cdc42-dependent actin assembly protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499838.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3B8, Q9XUS7
    Conserved Domains (3) summary
    cd07653
    Location:8 → 267
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11619
    Location:356 → 431
    HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11911
    Location:551 → 608
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUS7.2

Gene LinkOut

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