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rml-1 UTP--glucose-1-phosphate uridylyltransferase [ Caenorhabditis elegans ]

Gene ID: 176814, updated on 2-Nov-2024

Summary

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Official Symbol
rml-1
Official Full Name
UTP--glucose-1-phosphate uridylyltransferase
Primary source
WormBase:WBGene00010665
Locus tag
CELE_K08E3.5
See related
AllianceGenome:WB:WBGene00010665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rml-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (13764030..13768092, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene Transducer of Cdc42-dependent actin assembly protein 2 homolog Neighboring gene DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase parkin;RBR-type E3 ubiquitin transferase;Ubiquitin-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Yu Q, et al. Biochem J, 2012 Mar 1. PMID 22132858
  2. Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer. Pandey T, et al. EMBO J, 2023 Dec 11. PMID 37953666,
  3. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article
  4. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article
  5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in sarcomere HDA PubMed 
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
NP_001022671.1
  • Confirmed by transcript evidence
NP_001379213.1
  • Confirmed by transcript evidence
NP_001379395.1
  • Confirmed by transcript evidence
NP_499841.1
  • Confirmed by transcript evidence
NP_499842.1
  • Confirmed by transcript evidence
NP_499843.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13764030..13768092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067441.4 → NP_499842.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS5
    Conserved Domains (1) summary
    pfam01704
    Location:73 → 487
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  2. NM_001027500.7 → NP_001022671.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q69Z13
    Conserved Domains (1) summary
    pfam01704
    Location:44 → 458
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  3. NM_001392235.1 → NP_001379213.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS6
    Conserved Domains (1) summary
    pfam01704
    Location:58 → 474
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  4. NM_001392234.1 → NP_001379395.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86D12
    Conserved Domains (1) summary
    pfam01704
    Location:45 → 461
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  5. NM_067440.8 → NP_499841.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUS4
    Conserved Domains (1) summary
    pfam01704
    Location:62 → 476
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  6. NM_067442.6 → NP_499843.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499843.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQE5
    Conserved Domains (1) summary
    pfam01704
    Location:73 → 462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
Nucleotide Protein
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