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mdt-29 Mediator of RNA polymerase II transcription subunit 29 [ Caenorhabditis elegans ]

Gene ID: 176817, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-29
Official Full Name
Mediator of RNA polymerase II transcription subunit 29
Primary source
WormBase:WBGene00007025
Locus tag
CELE_K08E3.8
See related
AllianceGenome:WB:WBGene00007025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in body wall musculature. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-29 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (13773456..13778889)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase parkin;RBR-type E3 ubiquitin transferase;Ubiquitin-like domain-containing protein Neighboring gene Protection of telomeres protein 1 ssDNA-binding domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans. Xia D, et al. Dev Biol, 2009 Aug 15. PMID 19500563
  2. sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Chen J, et al. Genetics, 2004 Jan. PMID 15020414, Free PMC Article
  3. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
  4. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563
  5. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lateral inhibition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 29
NP_499847.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13773456..13778889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067446.8 → NP_499847.1  Mediator of RNA polymerase II transcription subunit 29 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XUS2
    Conserved Domains (2) summary
    pfam11568
    Location:294 → 434
    Med29; Mediator complex subunit 29
    cl18951
    Location:208 → 319
    Amidase; Amidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUS2.1

Gene LinkOut

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