frm-5.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: frm-5.1
Official Full Name: FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein
Primary source: WormBase:WBGene00001492
Locus tag: CELE_Y38C1AB.8
See related: AllianceGenome:WB:WBGene00001492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinase activity. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See frm-5.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 22

Sequence:: Chromosome: IV; NC_003282.8 (32463..48880, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38C1AB.b (e-PCR)
- UniSTS:323904

C15E6.1 (e-PCR)
- UniSTS:308564

T02H7.5 (e-PCR)
- UniSTS:305772

T02H7.9 (e-PCR)
- UniSTS:319599

T02H7.1 (e-PCR)
- UniSTS:320129

T05C7.1 (e-PCR)
- UniSTS:317601

Y38C1AB.e (e-PCR)
- UniSTS:324279

Y38C1AB.k (e-PCR)
- UniSTS:324280

Y38C1AB.g (e-PCR)
- UniSTS:322749

T02H7.10 (e-PCR)
- UniSTS:314856

Y38C1AB.f (e-PCR)
- UniSTS:324598

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein

NP_001255216.1

Confirmed by transcript evidence

NP_001255217.2

Confirmed by transcript evidence

NP_001408266.1

Confirmed by transcript evidence

NP_001408267.1

Confirmed by transcript evidence

NP_001408268.1

Confirmed by transcript evidence

NP_001408269.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

32463..48880 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268288.4 → NP_001255217.2 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255217.2

Status: REVIEWED

UniProtKB/TrEMBL

G4RT84, Q33BL4

Conserved Domains (6) summary

smart00295
Location:686 → 891

B41; Band 4.1 homologues

cd00992
Location:1113 → 1194

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13187
Location:887 → 1002

FERM_C_PTPH13; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor 13 (PTPH13)

pfam00373
Location:781 → 891

FERM_M; FERM central domain

pfam09379
Location:689 → 751

FERM_N; FERM N-terminal domain

cl21453
Location:9 → 164

PKc_like; Protein Kinases, catalytic domain
NM_001421336.1 → NP_001408267.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QC08
NM_001268287.2 → NP_001255216.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255216.1

Status: REVIEWED

UniProtKB/TrEMBL

H8W3Y2

Conserved Domains (6) summary

smart00295
Location:686 → 891

B41; Band 4.1 homologues

cd00992
Location:1127 → 1208

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00373
Location:781 → 891

FERM_M; FERM central domain

pfam09379
Location:689 → 751

FERM_N; FERM N-terminal domain

cl17171
Location:887 → 1016

PH-like; Pleckstrin homology-like domain

cl21453
Location:9 → 164

PKc_like; Protein Kinases, catalytic domain
NM_001421337.1 → NP_001408266.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QDD1
NM_001421338.1 → NP_001408269.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QGP1
NM_001421339.1 → NP_001408268.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCJ3