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daf-1 Cell surface receptor daf-1 [ Caenorhabditis elegans ]

Gene ID: 176829, updated on 2-Nov-2024

Summary

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Official Symbol
daf-1
Official Full Name
Cell surface receptor daf-1
Primary source
WormBase:WBGene00000897
Locus tag
CELE_F29C4.1
See related
AllianceGenome:WB:WBGene00000897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable activin binding activity; activin receptor activity, type I; and transforming growth factor beta receptor activity. Involved in several processes, including dauer entry; determination of adult lifespan; and response to bacterium. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including distal tip cell; ganglia; inner labial sensillum; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; carcinoma (multiple); fibrodysplasia ossificans progressiva; gastrointestinal system cancer (multiple); and glaucoma (multiple). Orthologous to several human genes including ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (132416..138081)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Cuticle collagen 99;Putative cuticle collagen 99 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Georgi LL, et al. Cell, 1990 May 18. PMID 2160853
  2. Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. De-Souza EA, et al. Nat Aging, 2023 Aug. PMID 37500972, Free PMC Article
  3. A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Morita K, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11353865, Free PMC Article
  4. Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry. Prasain JK, et al. Metabolites, 2015 Nov 11. PMID 26569325, Free PMC Article
  5. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Joshua GWP, et al. Microbiology (Reading), 2003 Nov. PMID 14600234

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptomic Profiling of DAF-7/TGFbeta Pathway Mutants in C. elegans.
    Title: Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of eating behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Cell surface receptor daf-1
NP_001023159.1
  • Confirmed by transcript evidence
NP_001023160.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    132416..138081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027988.6 → NP_001023159.1  Cell surface receptor daf-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023159.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20792
    Conserved Domains (3) summary
    smart00467
    Location:265 → 293
    GS; GS motif
    cd14056
    Location:297 → 589
    STKc_TGFbR_I; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors
    pfam07714
    Location:293 → 576
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001027989.6 → NP_001023160.1  Cell surface receptor daf-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20792
    Conserved Domains (3) summary
    smart00467
    Location:265 → 293
    GS; GS motif
    pfam07714
    Location:293 → 575
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:297 → 588
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20792.1

Gene LinkOut

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